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  • Title: Bone marrow transplantation in sickle cell anemia.
    Author: Hoppe CC, Walters MC.
    Journal: Curr Opin Oncol; 2001 Mar; 13(2):85-90. PubMed ID: 11224704.
    Abstract:
    Hematopoietic cell transplantation (HCT) is a treatment with curative potential for sickle cell disease (SCD). The experience of HCT for persons with beta-thalassemia major has been successfully extended to SCD. Currently, the event-free survival rate after allogeneic-matched sibling HCT for SCD is 82%. However, short-term and long-term transplant-related complications remain substantial barriers to HCT, particularly in older patients with life-long complications of SCD. Novel conditioning regimens that minimize transplant-associated toxicity have been developed and show promise for wider application of HCT. Alternative stem cell sources may also expand the availability of HCT for selected patients with SCD.
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