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  • Title: [Study of IL-6 signal transduction pathway in a human multiple myeloma cell line--Sko-007].
    Author: Song L, Li Y, Shen B.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 2000 Nov; 21(11):569-71. PubMed ID: 11225245.
    Abstract:
    OBJECTIVE: To investigate the IL-6 signal transduction pathway in a human multiple myeloma (MM) cell line--Sko-007. METHODS: The electrophoretic mobility shift assay (EMSA) and immunoprecipitation were used to detect the activation of IL-6-related transcription factors(TFs)--STAT3, NF-IL-6, NF-kB and protein kinase ERK, Jak1 in Sko-007 cells stimulated by IL-6. RESULTS: Both the transcription factors-STAT3, NF-IL-6 and protein kinases-Jak1, ERK were activated by IL-6 in Sko-007 cells. CONCLUSION: The biological function of IL-6 on Sko-007 cells is mediated by the activation of Jak/STAT and Ras/NF-IL-6 signal transduction pathways.
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