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  • Title: Determination of propoxyphene and norpropoxyphene by chemical ionization mass fragmentography.
    Author: Wolen RL, Ziege EA, Gruber CM.
    Journal: Clin Pharmacol Ther; 1975 Jan; 17(1):15-20. PubMed ID: 1122667.
    Abstract:
    The kinetics of propoxyphene and its primary metabolite, norpropoxyphene, have been simultaneously re-evaluated in man by using gas-liquid chromatography/mass spectrometry, deuterium-labeled mass internal standards, and multiple ion monitoring. Plasma concentrations in 4 volunteers determined for as long as 240 hr after single oral doses of 2 propoxyphene salts indicate the overall half-life of propoxyphene to be 11.8 hr and of norpropoxyphene to be 36.6 hr.
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