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  • Title: [Paraneoplastic acquired ichthyosis revealing non-Hodgkin's lymphoma].
    Author: Estines O, Grosieux-Dauger C, Derancourt C, Patey M, Durlach A, Bernard P.
    Journal: Ann Dermatol Venereol; 2001 Jan; 128(1):31-4. PubMed ID: 11226897.
    Abstract:
    BACKGROUND: Paraneoplastic ichthyosis is a rare affection generally associated with malignant hemopathy. CASE REPORT: A 61 year-old man was seen with a generalized ichthyosis associated with a palmoplantar hyperkeratosis developed over the last 2 years, and an axillary lymph node. Histology of the lymph node revealed a large cell anaplastic lymphoma. Both ichthyosis and palmoplantar keratosis totally disappeared three weeks after adenectomy, without any other treatment. DISCUSSION: This rapid and complete regression of ichthyosis, after the sole ablation of the involved lymph node confirmed the paraneoplastic nature of the disorders of the keratinization (ichtyosis, palmoplantar keratodermia). The review of the literature showed only one case characterized by a rapid disappearance of ichthyosis after surgical treatment of the malignant lymphoma.
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