These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Biochemical confirmation of an experimental osteoarthritis model.
    Author: Ehrlich MG, Mankin HJ, Jones H, Grossman A, Crispen C, Ancona D.
    Journal: J Bone Joint Surg Am; 1975 Apr; 57(3):392-6. PubMed ID: 1123393.
    Abstract:
    Section of the medial collateral and both cruciate ligaments combined with resection of the medial meniscus in rabbit knees caused instability and during the ensuing six months these knees showed progressive histological changes similar to those of human osteoarthritis. Biochemical analysis of the cartilage from such knee joints demonstrated a decrease in proteoglycan, an increase in acid phosphatase, and increases in the rates of synthesis of protein and glycosaminoglycan. These findings, which are quite consistent with those in human osteoarthritis, suggest that this animal model may be of value in the study of the pathogenesis and treatment of human disease.
    [Abstract] [Full Text] [Related] [New Search]