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  • Title: [A clinical analysis of combination treatment with brachytherapy and external radiation, plus chemotherapy for the treatment of esophageal cancer].
    Author: Zhong X, Yuan D, Yang L.
    Journal: Zhonghua Zhong Liu Za Zhi; 2000 Nov; 22(6):519-21. PubMed ID: 11235580.
    Abstract:
    OBJECTIVE: To analyse the value of various combinations of treatment for esophageal cancer. METHODS: One hundred twenty cases of esophageal cancer were randomly divided into four groups, 30 cases in each group. Group I was treated with external radiation (RT) alone; group II, with RT plus brachytherapy; group III with RT plus chemotherapy, and group IV with RT plus brachytherapy and chemotherapy. RT with 60Co was given 2 Gy daily, 5 times a week, with a total dose of 60-74 Gy. Brachytherapy was given 6-8 Gy once weekly with a total dose of 18-24 Gy. Chemotherapy with carboplatin was given 100 mg/day, five days a week at first and fifth week. RESULTS: The 1, 2, 3-year survival rate in group II, III and IV was higher than that in group I (P < 0.05). The 3-year survival rate of group I-IV patients was 13.3%, 36.7%, 40.0%, 46.7%, respectively. More patients died of cancer recurrence and progression in group I than in any of the other 3 groups of patients (P < 0.05). However, the frequency of distant metastasis was not significantly different. CONCLUSION: The combination treatment with external radiation, brachytherapy and chemotherapy can improve the local control of tumor growth and the survival rate in esophageal cancer patients.
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