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  • Title: Induction of carcinoma of the large intestine in guinea pigs by intratectal instillation of N-methyl-N-nitrosourea.
    Author: Narisawa T, Wong CQ, Weisburger JH.
    Journal: J Natl Cancer Inst; 1975 Mar; 54(3):785-7. PubMed ID: 1123856.
    Abstract:
    Intrarectal administration of 0.5 ml of a 0.25 percent solution of N-methyl-N-nitrosourea twice seekly for 42 weeks to female inbred strain-2 guinea pigs induced large-bowel adenocarcinomas in 9 of 10 animals in 38-56 weeks. Controls did not show cancer. The lesions were infiltrative or constrictive, which distinguished them from chemically induced large-bowel cancers of rats and mice.
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