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  • Title: [Cutaneous pyoderma gangrenosum with hepatosplenic localization and monoclonal gammapathy. A case report].
    Author: Delbrel X, Germain P, Fach J, Etienne G, Beylot C, Parrens M, De Mascarel A, Le Bras M, Longy-Boursier M.
    Journal: Ann Med Interne (Paris); 2001 Feb; 152(1):65-7. PubMed ID: 11240430.
    Abstract:
    Pyoderma gangrenosum is an ulcerative disease of the skin. The histopathological lesions are nonspecific, characterized by a diffuse neutrophilic infiltrate in the dermis. Pyoderma gangrenosum is associated with inflammatory, digestive or articular disease, or acute or chronic hemotology disorders in 50% of the cases, more rarely with monoclonal gammapathy. A visceral localization of pyoderma gangrenosum is rare, simulating a systemic disease or an underlying neoplasia. We report a case of cutaneous pyoderma gangrenosum with splenic and hepatic localizatios associated with an IgG monoclonal gammapathy. We emphasize the efficacy of immunosuppressor treatment and the importance of long-term monitoring of these patients.
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