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  • Title: Fasting hypoglycemia is common during maintenance therapy for childhood acute lymphoblastic leukemia.
    Author: Halonen P, Salo MK, Mäkipernaa A.
    Journal: J Pediatr; 2001 Mar; 138(3):428-31. PubMed ID: 11241057.
    Abstract:
    Nineteen of 35 children (54%) with acute lymphoblastic leukemia receiving maintenance therapy consisting of daily oral 6-mercaptopurine and weekly oral methotrexate developed hypoglycemia (blood glucose level <2.7 mmol/L [50 mg/dL] or <2.9 mmol/L [54 mg/dL] with symptoms) during 16 hours of overnight fasting. In 15 of 15 re-studied children, fasting tolerance had improved, and in 67% (10/15), it had become normal a few months after cessation of therapy.
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