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  • Title: Recent advances in the cytogenetic study of human spontaneous abortions.
    Author: McConnell HD, Carr DH.
    Journal: Obstet Gynecol; 1975 May; 45(5):547-52. PubMed ID: 1124170.
    Abstract:
    A cytogenetic study of 27 spontaneous abortions was carried out using the Q-banding technic. The specimens were selected for study in order to increase the likelihood of finding a chromosome anomaly. Sixteen of 27 specimens (59%) showed a chromosome abnormality. Trisomy was found in 9 of the specimens, and the chromosomes involved were Nos. 2, 8, 14, 16, and 22. There were 5 triploids and 2 tetraploids. Using marker chromosomes, it was found that the extra haploid set was paternally derived in two of the triploids which were favorable for study. The Q-banding technic provides accurate identification of the extra chromosomes in trisomy. When favorable markers are present in the parents, the source of the extra haploid set can be identified in triploid abortuses. A cytogenic study of 27 spontaneously aborted fetuses using the Q-binding technique is presented. Chromosomal abnormalities were detected in 59% of the specimens. Trisomy was indicated in 9 specimens, with chromosomes Nos. 2, 8, 14, 16, and 22 being involved. There were 5 cases of triploids and 2 cases of tetraploids. Extra haploid sets were paternally derived in 2 of the triploids. The Q-binding technique can accurately identify the parental source of the extra haploid set in triploids when favorable markers are present in the parents.
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