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  • Title: [Application of IHW2 purged bone marrow to autologous bone marrow transplantation in the treatment of acute myeloid leukemia].
    Author: Jiang R, Han M, Zhao Y.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 1998 Jun; 19(6):312-4. PubMed ID: 11243113.
    Abstract:
    OBJECTIVE: To observe the clinical effectiveness of IHW2 purged autologous bone marrow transplantation (ABMT) in the treatment of AML patients. METHODS: Large volume of bone marrow was purged in vitro by IHW2 and then reinfused to patients for ABMT. RESULTS: All of the three patients transplanted with IHW2 purged autologous bone marrow successfully reconstituted hemopoiesis. Two patients got continuous complete remission for 36+ and 34+ months, respectively. The karyotype of one of the two patient was 46,XY,del(16)(q22) before ABMT and changed to 46,XY in 2 months after transplantation. The third patient relapsed after ABMT 19 months. CONCLUSION: The preliminary study suggests that IHW2 may have certain purging effect on leukemic cells and is safe for clinical application.
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