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  • Title: [RBC-CR1 genotype polymorphism and RBC immune function in childhood ITP].
    Author: Guo S, Zhou L, Wang H.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 1998 Mar; 19(3):143-5. PubMed ID: 11243146.
    Abstract:
    OBJECTIVE: To investigate the RBC immune functions in childhood idiopathic thrombocytopenic purpura (ITP). METHODS: RBC-CR1 polymorphism genotype, RBC immune function and its regulator function were detected in 22 ITP, 30 allergic purpura (AP) and 50 normal children by PCR and Guo Feng's method. RESULTS: 1. There were 18 cases of high expression (82%) and 4 of medium expression (18%) of RBC-CR1 genotypes in the ITP cases. The rate of the medium expression genotype was significantly higher in ITP than that in AP and normal children (P < 0.01). 2. The rates of RBC-C3bRR and RBC-C3bRFER were much lower (P < 0.01), and the rates of RBC-ICR and RBC-C3bRFIR were significantly higher in ITP than those in normal children (P < 0.01). 3. RBC-CR1 genotypes in ITP were correlated negatively with RBC-C3bRR and RBC-C3bRFER (P < 0.05), but positively with RBC-ICR and RBC-C3bRFIR (P < 0.05). CONCLUSION: RBC immune participated in the pathogenesis of ITP.
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