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  • Title: The stability of 6-mercaptopurine riboside in neutral and basic medium.
    Author: Jelińska A, Magdziarz M.
    Journal: Acta Pol Pharm; 2000; 57(6):407-9. PubMed ID: 11243244.
    Abstract:
    The kinetics of hydrolysis of 6-mercaptopurine riboside (R-6-MP) was studied in aqueous solutions over the pH range of 6.11-12.13 at 353 K. The decomposition was investigated by HPLC method. At the pH range from 6.11 to 12.13 hydrolysis of 6-mercaptopurine riboside includes: spontaeous hydrolysis of non-protonated R-6-MP molecules mono- and di-anions R-6-MP molecules under the effect of water.
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