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  • Title: [The relationship between HBV infection and injury of tubuli and interstitium in IgA nephropathy].
    Author: Ma X, Zhang Y, Fang L.
    Journal: Zhonghua Bing Li Xue Za Zhi; 1998 Aug; 27(4):269-72. PubMed ID: 11244995.
    Abstract:
    OBJECTIVE: To clarify the correlation between HBV infection and the injury of tubuli and interstitium of IgA nephropathy. METHODS: Renal biopsy specimens from 91 patients with primary IgA nephropathy were investigated by use of in situ hybridization (HBV DNA), immunohistochemistry (HBsAg, HBcAg, CD3, CD8) and HBV DNA, HBAg-CD43 double staining techniques. RESULTS: The positive rate of HBAg in renal tissue as detected by immunohistochemistry was 69.2% and that of HBV DNA detected by in situ hybridization was 42.9%. Double staining showed that HBV DNA positive tubular epithelial cells might coexpress HBsAg and/or HBcAg. The numbers of the infiltrated CD3+ cells and CD8+ cells in cases with positive HBV infections markers were significantly higher than those of cases without infection (P < 0.01). In addition, CD43+ T lymphocytes infiltrated around or invaded into the tubuli walls which had positive HBcAg or HBsAg expression. CONCLUSION: After HBV infection, the renal cells could express HBAg and induce infiltration of CD3+ cells and CD8+ cells, resulting in aggravation of the injury of tubuli and interstitium. Therefore, it is considered that HBV infection might play an important role in the occurrence and progress of IgA nephropathy.
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