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  • Title: Anti-alpha-fodrin autoantibody is an early diagnostic marker for childhood primary Sjögren's syndrome.
    Author: Kobayashi I, Kawamura N, Okano M, Shikano T, Mizumoto M, Hayashi Y, Kobayashi K.
    Journal: J Rheumatol; 2001 Feb; 28(2):363-5. PubMed ID: 11246678.
    Abstract:
    OBJECTIVE: alpha-fodrin is a recently identified autoantigen associated with adult primary Sjögren's syndrome (SS). We tested whether anti-alpha-fodrin antibody could also be used as a diagnostic marker for childhood SS. METHODS: We performed immunoblot analysis of sera from 7 patients with childhood primary SS using glutathione-S-transferase alpha-fodrin fusion protein as an antigen. RESULTS: Anti-alpha-fodrin antibody was detected in sera from all 7 patients with childhood primary SS, 2 of 4 with secondary SS, and one of 7 with systemic lupus erythematosus, but in no other healthy controls. CONCLUSION: The anti-alpha-fodrin autoantibody was detected before anti-SSA or SSB antibody became positive; thus anti-alpha-fodrin antibody could be a useful marker for the early diagnosis of SS.
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