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  • Title: [Use of atomic force microscopy to study the morphology and structure of viruses].
    Author: Polishchuk VP, Tyvonchuk TP, Rengevich IeV, Beketov GV, Budzanivskaia IG, Boĭko AL.
    Journal: Mikrobiol Z; 2000; 62(6):40-3. PubMed ID: 11247349.
    Abstract:
    The paper describes AFM methodic approaches in the investigation of viruses (TMV, phage T4). A possibility is shown to use this method to obtain high-quality three-dimensional image of objects without additional treatment with salts of heavy metals. The phage T4 was also a model to study the object density, using the phase shift of the AFM. Such researches can determine the internal structure of a virion and folding of nucleic acid inside a virion.
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