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  • Title: Linkage and allelic association of chromosome 5 cytokine cluster genetic markers with atopy and asthma associated traits.
    Author: Walley AJ, Wiltshire S, Ellis CM, Cookson WO.
    Journal: Genomics; 2001 Feb 15; 72(1):15-20. PubMed ID: 11247662.
    Abstract:
    Linkage and association of polymorphic markers in the chromosome 5q31-q33 cytokine cluster to atopy and asthma associated phenotypes have been reported by a number of groups. To investigate this region, 29 polymorphic markers were used to genotype a combined set of 233 families. These markers were ordered based upon the genetic data, supplemented by published genetic and physical maps. Significant two-point linkage was observed for asthma (most significant marker IRF1, P = 0.0002) and atopy (CD14SNP, P = 0.0001). Allelic association was observed between D5S463 and atopy (P = 0.002) and the skin prick test index (P = 0.04). The data support the possibility of three asthma/atopy loci in the 5q31-q33 region, each with a relatively small effect.
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