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  • Title: Ion exchange chromatographic determination of olpadronate, phosphate, phosphite, chloride and methanesulfonic acid.
    Author: Quattrocchi O, Frisardi L, Iglesias M, Noya M, Caputto M, Ferraris D, Siliprandi D, Piccinni E.
    Journal: J Pharm Biomed Anal; 2001 Mar; 24(5-6):1011-8. PubMed ID: 11248496.
    Abstract:
    A method based on single column ion chromatography with UV detection was developed for purity testing and assay of monosodium olpadronate. The analyte aqueous solution is precipitated with methanol to enhance the impurities/olpadronate molar ratio, thus improving purity determination at trace levels. The resulting solution is injected into a standard chromatographic system with UV detector in indirect mode with a Waters IC Pak HR column using diluted nitric acid as the mobile phase. The method was fully validated according to ICH guidelines for the determination of phosphite, phosphate, chloride and methanesulfonic acid in olpadronate being suitable for purity testing and assay.
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