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  • Title: Triplex-forming molecules for modulation of DNA information processing.
    Author: Giovannangeli C, Hélène C.
    Journal: Curr Opin Mol Ther; 2000 Jun; 2(3):288-96. PubMed ID: 11249623.
    Abstract:
    The design of specific DNA ligands is an important challenge in biological and biomedical sciences. Targeting the source of genetic information may allow highly efficient gene-directed modulation of cell function. Triplex-forming molecules specifically recognize oligopyrimidine/oligopurine sequences by hydrogen bonding interactions. In cell cultures they have been used successfully to downregulate or upregulate transcription in a gene-specific manner or to induce site-directed mutagenesis and recombination. For biotechnological applications, triplex-forming molecules are powerful tools for gene-specific chemistry.
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