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  • Title: Targeting remodeling in respiratory inflammation.
    Author: Knox AJ, Pang L, Zhu YM.
    Journal: Curr Opin Investig Drugs; 2000 Dec; 1(4):428-34. PubMed ID: 11249695.
    Abstract:
    Chronic asthma causes considerable morbidity, mortality and utilization of healthcare resources. The fact that asthma still causes such problems despite the widespread use of anti-inflammatory treatment suggests that new approaches are needed. Airways in chronic asthma are characterized by considerable remodeling which affects a number of structures, particularly airway smooth muscle and changes in airway smooth muscle thickness may be one of the most important determinants of bronchial hyperresponsiveness. Here we suggest new approaches that might be used to target smooth muscle remodeling in asthma.
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