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  • Title: [The effect of adrenaline and cyclophosphamide on the growth and blood supply of experimental Guérin carcinoma].
    Author: Khananaev LI, Fitsych SA.
    Journal: Biull Eksp Biol Med; 1975 Mar; 79(3):83-4. PubMed ID: 1125420.
    Abstract:
    Tests were conducted on albino rats with experimental Guerin carcinoma. A method of the blood vessel injection and preparation of lucid and stained (with hematoxylin-eosine) sections, and determination of the density of the capillary network were used; intramuscular adrenaline injections proved to produce an inhibitory effect on the growth of Guerin carcinoma, this bein accompanied by its intensified microvascularization. Combined administration of cyclophosphan and adrenaline produced a marked antitumour effect on accout of an antiblastic actionof cyclophosphan enhanced by adrenaline. The detected direct relationship between the vascular system of Guerin carcinoma, the thickness of the capillary network and the effect of the theraputic action of cyclophospahan and adrenaline pointed to the role played by the blood supply of Guerin carcinoma in the antiblastic action of cyclophosphan in case of combined administration with adrenaline.
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