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  • Title: Gram-positive and Gram-negative bacteria as carrier systems for DNA vaccines.
    Author: Dietrich G, Kolb-Mäurer A, Spreng S, Schartl M, Goebel W, Gentschev I.
    Journal: Vaccine; 2001 Mar 21; 19(17-19):2506-12. PubMed ID: 11257384.
    Abstract:
    Vaccination by intradermal or intramuscular injection of eukaryotic antigen expression vectors (so-called DNA vaccines) elicits strong cellular and humoral immune responses. A novel approach employs attenuated mutant strains of Gram-positive and Gram-negative intracellular bacteria as carriers for the delivery of DNA vaccines. This strategy allows the administration of the DNA vaccines via mucosal surfaces and a direct delivery of the plasmid DNA to professional antigen presenting cells (APC), such as macrophages and dendritic cells (DC). In this work, we have found that several Gram-negative bacteria are capable of delivering plasmid vectors to human DC. In addition, we tested the suitability of the Gram-positive bacterium Listeria monocytogenes as a vaccine carrier for the immunization of fish.
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