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  • Title: Case of spinocerebellar ataxia type 1 showing high intensity lesions in the frontal white matter on T2-weighted magnetic resonance images.
    Author: Nakayama T, Nakayama K, Takahashi Y, Ohkubo K, Tobe H, Soma M, Ozawa Y, Kanmatsuse K, Nakamura M, Hironaga T, Makizumi Y, Nagura H.
    Journal: Med Sci Monit; 2001; 7(2):299-303. PubMed ID: 11257739.
    Abstract:
    We report a case of genetically confirmed spinocerebellar ataxia type 1 (SCA1) in which magnetic resonance imaging (MRI) demonstrated a high signal intensity on T2-weighted images in the white matter of the frontal lobes. The patient was a 60-year-old Japanese man who complained of gait instability and speech difficulties. He was diagnosed as having spinocerebellar ataxia at the age of 46. A CAG repeat number of the patient was 48/26. Brain MRI showed marked atrophy of the cerebellum and brain stem. The high-signal intensity lesions on T2-weighted MRI in the white matter of the frontal lobes were evident in the periventricular regions. Such MRI abnormalities have not been described in SCA1 previously.
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