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  • Title: [Speed of ocular saccades in Huntington disease. Prospective study].
    Author: García Ruiz PJ, Cenjor C, Ulmer E, Hernández J, Cantarero S, Fanjul S, García de Yébenes J.
    Journal: Neurologia; 2001 Feb; 16(2):70-3. PubMed ID: 11257932.
    Abstract:
    BACKGROUND: Oculomotor abnormalities, especially slow saccades, have long been recognized in Huntington's disease (HD). OBJECTIVES AND METHODS: To study prospectively horizontal saccade velocity by videonystagmography in 21 patients with genetically confirmed HD. The study included a baseline analysis and a second evaluation after 18.8 +/- 7.1 months. We included a control group of 15 subjects. RESULTS: HD group exhibited decreased saccade velocity when compared with that from a control group (for predictive and unpredictive target). HD patients showed decreased saccade velocity with the passage of time (for predictive target, p < 0.01). Finally we found statistical significant correlation between saccade velocity and triplet length. CONCLUSIONS: The measurement of saccade velocity might be an objective method to study the natural evolution of HD, and thus evaluate the effectiveness of future therapies.
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