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  • Title: Hypertrophic osteoarthropathy: an unusual manifestation in nasopharyngeal cancer.
    Author: Biswal BM, Kareem A, Ahmed NM.
    Journal: Australas Radiol; 2001 Feb; 45(1):71-3. PubMed ID: 11259979.
    Abstract:
    A patient with nasopharyngeal carcinoma developed clubbing and hypertrophic osteoarthropathy 6 months before radiological detection of secondary deposits in the lung. Another patient with nasopharyngeal carcinoma developed digital clubbing and hypertrophic osteoarthropathy 6 months after the discovery of lung metastases. Development of a paraneoplastic syndrome in the form of hypertrophic osteoarthropathy and digital clubbing is very rare. This manifestation of nasopharyngeal cancers is presented, with a short review of its biology and pathogenesis.
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