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  • Title: New chiral crown ether stationary phase for the liquid chromatographic resolution of alpha-amino acid enantiomers.
    Author: Hyun MH, Han SC, Lipshutz BH, Shin YJ, Welch CJ.
    Journal: J Chromatogr A; 2001 Mar 02; 910(2):359-65. PubMed ID: 11261730.
    Abstract:
    A new chiral stationary phase (CSP) for the liquid chromatographic separation of enantiomers was prepared by bonding a novel enantiopure (diphenyl-substituted 1,1'-binaphthyl) crown ether to 5 microm silica gel. The resulting CSP was applied to the separation of the enantiomers of various natural and unnatural alpha-amino acids. All alpha-amino acids tested were resolved very well on the new CSP, with the exception of proline, which does not contain a primary amino group. The resolution of alpha-amino acid enantiomers on this new CSP was found to be dependent on the type and amounts of organic and acidic modifiers, and on column temperature.
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