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  • Title: [Expression of endothelin-1 and endothelin-1 mRNA in placental villus of pregnancy induced hypertension and the changes of plasma endothelin-1].
    Author: Tong X, Li S, Zhao Y.
    Journal: Zhonghua Fu Chan Ke Za Zhi; 1999 Jan; 34(1):11-3. PubMed ID: 11263164.
    Abstract:
    OBJECTIVE: To investigate the role of endothelin (ET-1) in the pathogenesis of pregnancy induced hypertension (PIH). METHODS: In 70 cases of PIH the plasma concentration of ET-1 was measured by RIA, and the expressions of ET-1 and its mRNA in placental villus were determined by immunohistochemistry and in situ hybridization respectively. 30 normal pregnant women (NP) served as control group. RESULTS: (1) The Plasma concentration of ET-1 was significantly higher in PIH than that in NP. There was a positive correlation between the plasma ET-1 level and mean arterial pressure in PIH. (2) The expressions of ET-1 and ET-1 mRNA were found in syncytiotrophoblast of placental villus and in the endothelium of fetal vessels. These positive signals were higher in PIH than in NP. CONCLUSION: The injury of endothelium of fetal and placental blood vessels was one of the causes of PIH. The placenta may play an important role in the pathogenesis of PIH.
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