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  • Title: [Effect of liposome-C-erbB2 antisense oligodeoxynucleotides on the growth and the chemotherapeutic drug sensitivity of human ovarian cancer transplanted in the omentum of nude mice].
    Author: Shen M, Feng Y, Zhou X.
    Journal: Zhonghua Fu Chan Ke Za Zhi; 1999 Feb; 34(2):110-2. PubMed ID: 11263196.
    Abstract:
    OBJECTIVE: To investigate the effects of liposome-C-erbB2 antisense phosphorothioate oligodeoxynucleotides(S-ODNs) on the growth and the chemotherapeutic drug sensitivity of human ovarian cancer transplanted in the omentum of nude mice. METHODS: Human ovarian cancer transplanted in the omentum of nude mice model was established, then divided into four groups: control group, experimental group, chemotherapeutic group, and experimental + chemotherapeutic group. Different treatments were given respectively. The weight of nude mice was observed and the morphology of tumor cells was observed by electromicroscope. RESULTS: The growth inhibitory rate in the experimental group was 37%. There were more heterochromatins in the treated tumor cells. The growth inhibitory rate in the experimental + chemotherapeutic group was increased to 50%. There was no obvious alteration in the weight of experimental group. CONCLUSION: The data in this study suggest that antisense therapy is an useful method of gene therapy in ovarian cancer; Moreover, it could enhance the effectiveness of antitumor drug.
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