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  • Title: [Study of morphologic effects of 4 Chinese herbs by bone histomorphometry in ovariectomized rats].
    Author: Ma Z, Wang R, Qiu M.
    Journal: Zhonghua Fu Chan Ke Za Zhi; 1999 Feb; 34(2):82-5. PubMed ID: 11263203.
    Abstract:
    OBJECTIVE: To study the therapeutic effects of Chinese herbs Drynaria, Cynomorium, Epimedium and Chain Fern on osteoporotic ovariectomized (OVX) rat models. METHODS: 54 Wistar female rats at the age of 3 months were randomly divided into 2 groups: control groups and experimental group. The control group included: normal groups (N), shamed oprations group(S) and ovariectomized group (OVX) (10 in each group); The experimental group: group A (Drynaria), group B (Cynomorium), group C (Epimedium) and group D (Chain Fern) (6 in each group). Each of the experimental groups was fed separately with the 4 Chinese herbs (0.25 g/100 g B.W/day) respectively by mouth every day for 2 months. Double tetracycline labels were carried out on these animals before the sacrifice. Their left tibia was reserved for the preparation of bone specimen and was studied by bone histomorphometry. RESULTS: The percentage of trabecular volume in total bone volume (TV/TBV) decreased significantly in OVX rats as compared with shame group (P < 0.01). However, after treatment with Drynaria or Epimedium, TV/TBV increased significantly as compared with that before treatment (P < 0.05). The surface area of tetracycline label in Drynaria group lowered and osteoid percentage increased in Epimedium group. CONCLUSIONS: The 4 Chinese herbs have some therapeutic effects on osteoporotic rat models. Drynaria and Epimedium appeared to work better.
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