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  • Title: [Effect of WT1 gene expression on cell growth and proliferation in myeloid leukemia cell lines].
    Author: Mi Y, Wang L, Bian S.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 1998 Dec; 19(12):627-30. PubMed ID: 11263329.
    Abstract:
    OBJECTIVE: To explore the effect of WT1 antisense oligonucleotide(AS-oligo) on cell proliferation and apoptosis in myeloid leukemia cell lines. METHODS: K562 and HL-60 cells were cultivated with WT1 AS-oligo. The cell proliferation, apoptosis, cell cycle and gene expression were examined by MTT colorimetry, FACS and RT-PCR. RESULTS: WT1 AS-oligo could inhibit the proliferation of K562 cell and induce apoptosis of K562 and HL-60 cells. On the contrary, the growth of HL-60 cells and the expression of WT1, mdm2 and bcl-2 genes were unaffected. CONCLUSION: WT1 gene is related to the proliferation and apoptosis of leukemic cells. WT1 gene could suppress cell apoptosis independent of status of p53 and bcl-2 genes. It might play an role in leukemogenesis.
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