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  • Title: [Clinical analysis of 164 cases Coombs test positive autoimmune hemolytic anemia].
    Author: Zhang Y, Chu Y, Chen G.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 1998 Nov; 19(11):573-5. PubMed ID: 11263340.
    Abstract:
    OBJECTIVE: To analyze the clinical features and treatment outcomes of autoimmune hemolytic anemia (AIHA). METHODS: Coombs test positive AIHA patients were retrospectively analyzed. RESULTS: Patients with AIHA were predominantly female, secondary AIHA accounted for 49% of the total cases, mainly associated with connective tissue diseases. In most cases of AIHA, the anti-red cell antibodies were IgG plus C3, while patients with IgG plus IgM had more severe clinical manifestations. The response rate of adrenocortical hormones and cyclosporin A (CsA) was 90.9%. CONCLUSION: Adrenocorticosteroids is still the first choice of therapy for AIHA, CsA can improve the response rate.
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