These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Relationship between catalase activity, KatG gene and isoniazid-resistance in M. tuberculosis].
    Author: Wang X, Han Q, Liang B.
    Journal: Zhonghua Jie He He Hu Xi Za Zhi; 1998 Mar; 21(3):174-7. PubMed ID: 11263357.
    Abstract:
    OBJECTIVE: To investigate the relationship between catalase activity, KatG gene, gene mutation and INH-resistance in M. tuberculosis. METHOD: Catalase activities in 58 M. tuberculosis isolates were tested, and KatG gene mutations were detected further by PCR-SSCP. RESULT: None of INH-sensitive isolates lacked KatG sequences and all expressed catalase. 8(25%) INH-resistant isolates did not express catalase and 3(10%) lacked KatG gene, most of which were strains of high levels of resistance (MIC > 50 micrograms/ml). 8 INH-resistant isolates were analyzed further by PCR-SSCP and all were found to have KatG gene mutation. CONCLUSION: These findings indicated that lacking of catalase activity and KatG gene deletion occurred mainly in those highly INH-resistant strains, gene mutation other than complete deletion of KatG gene may be the major mechanism of INH-resistance.
    [Abstract] [Full Text] [Related] [New Search]