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  • Title: Asymmetric synthesis of the northern half C1-C16 of the bryostatins.
    Author: Vakalopoulos A, Lampe TF, Hoffmann HM.
    Journal: Org Lett; 2001 Mar 22; 3(6):929-32. PubMed ID: 11263918.
    Abstract:
    Starting from 8-oxabicyclo[3.2.1]oct-6-en-3-one and racemic 2,2-dimethyl-8-oxabicyclo[3.2.1]oct-6-en-3-one, the C1-C16 segment of the bryostatins has been synthesized in 30 steps and 9% overall yield (17 steps longest linear sequence). Fragment coupling by dithiane strategy and protecting group manipulations provided an advanced chemodifferentiated northern half segment.
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