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  • Title: Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase.
    Author: Brown P, Eggleston DS, Haltiwanger RC, Jarvest RL, Mensah L, O'Hanlon PJ, Pope AJ.
    Journal: Bioorg Med Chem Lett; 2001 Mar 12; 11(5):711-4. PubMed ID: 11266175.
    Abstract:
    Novel inhibitors of bacterial tyrosyl tRNA synthetase have been synthesised in which the cyclic hydroxylamine moiety of SB-219383 is replaced by C-pyranosyl derivatives. Potent and selective inhibition of bacterial tyrosyl tRNA synthetase was obtained.
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