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  • Title: [Spontaneous regression and leukoderma in malignant melanoma].
    Author: Happle R, Schotola I, Macher E.
    Journal: Hautarzt; 1975 Mar; 26(3):120-3. PubMed ID: 1126845.
    Abstract:
    In four patients with superficial spreading melanoma, partial spontaneous regression and/or leukodermas of different appearance occurred. In two patients leukoderma appeared within the central area of the primary tumor; one of whom developed, in addition, vitiligo elsewhere on the body. In a further case the melanoma exhibited a depigmented halo resembling Sutton's nevus. Presumably, these leukodermas represent an epiphenomenon of the specific immunological reaction between the host and the melanoma.
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