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  • Title: Inhibitory effect of dopamine on Ca(2+)-calmodulin-dependent protein kinase II activity in rat hippocampal slices.
    Author: Hou XY, Zhang GY.
    Journal: Zhongguo Yao Li Xue Bao; 1999 Oct; 20(10):902-6. PubMed ID: 11270989.
    Abstract:
    AIM: To study the effect of dopamine (DA) on Ca(2+)-calmodulin dependent protein kinase II (CCDPK II) activity in rat hippocampus. METHODS: Using rat hippocampal slices as an in vitro model, the activity of CCDPK II was examined by the method of 32P-incorporation. RESULTS: Exogenous DA reduced CCDPK II activity in hippocampal slices in a concentration- and time-dependent manner. Removal of extracellular calcium antagonized the DA-induced inhibition of CCDPK II activity, partially or completely. The activity of CCDPK II was markedly decreased by apomorphine (a nonselective DA receptor agonist), SKF38393 (a selective D1-like DA receptor agonist), or quinpirole (a selective D2-like DA receptor agonist). The inhibition of CCDPK II activity induced by exogenous DA was abolished by preincubation with Sch-23390, a selective D1-like DA receptor antagonist, or domperidone, a selective D2-like DA receptor antagonist. CONCLUSION: DA has an inhibitory effect on CCDPK II activity in rat hippocampus, related to stimulation of D1-like and D2-like receptors and calcium influx.
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