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  • Title: Human chronic kidney allograft rejection is accompanied by increased intraglomerular cathepsin B and L activity.
    Author: Paczek L, Pazik J, Teschner M, Schaefer RM, Rowinski W, Szmidt J, Lao M, Abgarowicz K, Gradowska L, Morzycka-Michalik M, Heidland A.
    Journal: Transpl Int; 1994; 7 Suppl 1():S311-3. PubMed ID: 11271236.
    Abstract:
    The major reason for late graft losses is chronic rejection. Recently, a large number of studies have indicated that proteolytic enzymes play an important role as mediators of glomerular injury. The cysteine proteinases cathepsins B and L degrade structural matrix proteins such as type I collagen and laminin. We investigated intraglomerular protease activities in 12 patients after kidney graftectomy because of end-stage renal disease following chronic rejection. A group of 12 patients undergoing nephrectomy because of cancer served as controls using only non-involved parts of the kidney. The activities of cathepsins B and L in homogenates of isolated glomeruli were measured fluorometrically methylcoumarylamide substrates and related to DNA content. In rejected kidney allografts we observed significantly enhanced intraglomerular cathepsin B activity and cathepsin B + L activity.
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