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  • Title: Morphine withdrawal-facilitated aggression is attenuated by morphine-conditioned stimuli.
    Author: Sukhotina IA.
    Journal: Pharmacol Biochem Behav; 2001 Jan; 68(1):93-8. PubMed ID: 11274713.
    Abstract:
    There is a considerable body of evidence indicating that stimuli associated with drug administration may become conditioned and evoke drug-like effects. The purpose of this study was to evaluate the ability of morphine-paired stimuli to affect an expression of morphine withdrawal-facilitated aggression. Individually housed aggressive adult mice were subjected to the repeated subcutaneous administration of morphine (twice a day, 8 days, increasing doses 10-80 mg/kg). Morphine treatment cessation facilitated an aggressive behaviour of animals during the second day of withdrawal. Subcutaneous but not intraperitoneal injection of saline attenuated the aggressive behaviour in morphine-withdrawn mice. These results suggest that the site of drug injection may serve as a conditioned stimulus.
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