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  • Title: [Acute intracranial hypertension and anicteric cholestasis revealing Whipple's disease without digestive involvement].
    Author: Lévy S, Degott C, Redondo A, Benhamou JP, Bernuau J.
    Journal: Gastroenterol Clin Biol; 2001 Jan; 25(1):100-2. PubMed ID: 11275624.
    Abstract:
    Whipple's disease is a rare infectious disease with potential central nervous system manifestations and a poor prognosis. We report the case of a young woman who presented with acute intracranial hypertension associated with cholestasis which revealed Whipple's disease without digestive involvement. The diagnosis was supported by the presence of PAS-diastase positive hepatic granulomas. A long course of antibiotics resulted in complete remission of the disease without relapse. An acute neurologic syndrome associated with cholestasis should suggest Whipple's disease.
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