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  • Title: Effect of physical training on sulfamethazine acetylation rate.
    Author: Abzalov RA, Nigmatullina RR, Khairullina GN, Garmonov SY, Shakirova LS, Evgen'ev MI.
    Journal: Bull Exp Biol Med; 2000 Dec; 130(12):1141-3. PubMed ID: 11276304.
    Abstract:
    We studied the rate of sulfamethazine acetylation in athletes and untrained controls aging 18-22 years. The rate of sulfamethazine acetylation in controls was characterized by a bimodal distribution: rapid and slow acetylators constituted 42 and 58%, respectively. The rate of sulfamethazine biotransformation in athletes was characterized by a trimodal distribution: ultrarapid, rapid, and slow xenobiotic acetylators constituted 48.4, 22.6, and 29%, respectively. The ultrarapid acetylation phenotype was probably associated with N-acetyltransferase induction and reflected adaptation to physical exercises
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