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  • Title: Carcinogenicity of three dose levels of 1,4-Bis(4-fluorophenyl)-2-propynyl-N-cyclooctyl carbamate in male Sprague-Dawley and F344 rats.
    Author: Weisburger EK, Ulland BM, Schueler RL, Weisburger JH, Harris PN.
    Journal: J Natl Cancer Inst; 1975 Apr; 54(4):975-9. PubMed ID: 1127726.
    Abstract:
    Feeding 1,4-bis(fluorophenyl)-2-propynyl-N-cyclooctyl carbamate to F344 or Sprague-Dawley male rats at 125-500 ppm in the diet led to many carcinomas of the small intestine and ear duct (Zymbal's gland tumors) in addition to lymphomas and leukemias. A high incidence of mammary adenocarcinomas was found in the Sprague-Dawley rats. Only a few colon or liver tumors were observed in each strain.
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