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  • Title: Tumor suppression by pyran copolymer: correlation with production of cytotoxic macrophages.
    Author: Harmel RP, zbar B.
    Journal: J Natl Cancer Inst; 1975 Apr; 54(4):989-92. PubMed ID: 1127729.
    Abstract:
    Intraperitoneal administration of pyran copolymer (pyran-2-succinic anhydride-4,5-dicarboxytetrahydro-6-methylanhydride polymer) protected C3H/HeN male mice against tumor development after intradermal challenge with cells of the transplantable, methylcholanthrene-induced, syngeneic fibrosarcoma 1038. Peritoneal cells from pyran-treated but not from normal animals suppressed tumor development in local passive-transfer experiments. Adherent peritoneal cells from pyran-treated mice were cytotoxic in vitro to several syngeneic murine tumor cell lines including 1038.
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