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  • Title: Sequence recognition of DNA by lexitropsins.
    Author: Goodsell DS.
    Journal: Curr Med Chem; 2001 Apr; 8(5):509-16. PubMed ID: 11281838.
    Abstract:
    Lexitropsins are modular polyamide molecules that are designed to "read" the base sequence of DNA. Lexitropsins constructed of three types of subunits--pyrrole, imidazole and hydroxypyrrole--allow full recognition of DNA base sequences. Structural studies have revealed the atomic basis of this specificity. Theoretical studies have explored the effectiveness of lexitropsins in targeting a given sequence within a genome, and have been used to analyze and improve lexitropsin design.
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