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  • Title: An association between clozapine-induced agranulocytosis in schizophrenics and HLA-DQB1*0201.
    Author: Amar A, Segman RH, Shtrussberg S, Sherman L, Safirman C, Lerer B, Brautbar C.
    Journal: Int J Neuropsychopharmacol; 1998 Jul; 1(1):41-44. PubMed ID: 11281944.
    Abstract:
    A group of 18 Israeli, clozapine-treated, schizophrenia patients underwent molecular and serological HLA typing in order to determine whether the major histocompatibility complex is associated with the development of clozapine-induced agranulocytosis. While under treatment with clozapine, 2 of the 18 patients developed agranulocytosis (total white blood cell count <3000/mm(3) and absolute polymorphonuclear count <500/mm(3)) and 3 developed granulocytopenia (total white blood cell count <3500/mm(3) and absolute polymorphonuclear count <1000/mm(3)). HLA-DQB1*0201 was present in all five patients who developed agranulocytosis or granulocytopenia (5/5; 100%), but in only 54% (7/13) of the patients who did not develop those complications. These findings indicate that DQB1*0201 or a gene located nearby could be involved in clozapine-induced agranulocytosis.
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