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  • Title: The cap-to-tail guide to mRNA turnover.
    Author: Wilusz CJ, Wormington M, Peltz SW.
    Journal: Nat Rev Mol Cell Biol; 2001 Apr; 2(4):237-46. PubMed ID: 11283721.
    Abstract:
    The levels of cellular messenger RNA transcripts can be regulated by controlling the rate at which the mRNA decays. Because decay rates affect the expression of specific genes, they provide a cell with flexibility in effecting rapid change. Moreover, many clinically relevant mRNAs--including several encoding cytokines, growth factors and proto-oncogenes--are regulated by differential RNA stability. But what are the sequence elements and factors that control the half-lives of mRNAs?
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