These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Effects of epimedium on the expression of interleukin-6 messenger ribonucleic acid in bone of ovariectomized rat].
    Author: Wang B, Quan J, Guo S.
    Journal: Zhonghua Fu Chan Ke Za Zhi; 2000 Dec; 35(12):724-6. PubMed ID: 11286030.
    Abstract:
    OBJECTIVE: To investigate the effects of the traditional herb-epimedium on the expression of interleukin-6 (IL-6) mRNA in bone of ovariectomized rat. METHODS: Forty female rats were randomly allocated into 4 groups, 10 in each: ovariectomized (OVX) group, sham operation group, OVX followed by epimedium (group 3) or nilestriol (group 4) for 3 months respectively. All rats were then sacrificed, and total RNA were directly isolated from their right tibia. Interleukin-6 mRNA expression was detected by relative semiquantitative reverse transcription-polymerase chain reaction technique. Lumbar bone mineral density (BMD) was measured by dual-energy X ray absorptiometry before sacrifice. RESULTS: The BMD of epimedium group was significantly higher than that in the OVX group (P < 0.05). On the contrary, the IL-6 mRNA expression level of epimedium group was significantly lower than that in the OVX group (P < 0.01), but higher than those in the sham and nilestrial group (P < 0.01). CONCLUSIONS: IL-6 may play a role in the pathogenesis of postmenopausal teoporosis. Epimedium can inhibit the expression of IL-6 mRNA, which may contribute to its anti-resorptive effect.
    [Abstract] [Full Text] [Related] [New Search]