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  • Title: [The association of diabetic disease with Friedreich's disease in members of the same family].
    Author: Greco AV, Ghirlanda G, Cocchi A, Fedeli G, Rebuzzi AG.
    Journal: Minerva Med; 1975 May 05; 66(34):1608-17. PubMed ID: 1128808.
    Abstract:
    Friedreigh's disease is only rarely associated with diabetes mellitus and only few cases are to be found in the literature, especially as regards siblings. Three cases of this association in members of two different families are reported. Two of the patients died from cardiovascular complication; the third case is that of a 32-yr-old woman who was able to complete a pregnancy. The pathogenesis of the association is discussed and a number of theories are put forward. The most generally accepted genetic hypothesis makes it possible to explain under a common metabolic denominator neurological disturbances and those in other systems. The association is not a purely casual event but is perhaps dependent on either two different genes or on a single gene with pleitropic effect. Heart signs are frequent in Friedreich's disease and brief mention is made of these.
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