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  • Title: Treatment of severe apnea in prematures with orally administered theophylline.
    Author: Uauy R, Shapiro DL, Smith B, Warshaw JB.
    Journal: Pediatrics; 1975 May; 55(5):595-8. PubMed ID: 1128984.
    Abstract:
    Twelve premature infants with primary apnea were treated with theophylline as an alternative to mechanical ventilation. There was a significant (P smaller than .005) reduction in the mean daily number and the severity of apneic episodes after treatment. The only significant side effect noted was a rise in heart rate.
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