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  • Title: CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin.
    Author: Basu S, Binder RJ, Ramalingam T, Srivastava PK.
    Journal: Immunity; 2001 Mar; 14(3):303-13. PubMed ID: 11290339.
    Abstract:
    Complexes of the heat shock protein gp96 and antigenic peptides are taken up by antigen-presenting cells and presented by MHC class I molecules. In order to explain the unusual efficiency of this process, the uptake of gp96 had been postulated to occur through a receptor, identified recently as CD91. We show here that complexes of peptides with heat shock proteins hsp90, calreticulin, and hsp70 are also taken up by macrophages and dendritic cells and re-presented by MHC class I molecules. All heat shock proteins utilize the CD91 receptor, even though some of the proteins have no homology with each other. Postuptake processing of gp96-chaperoned peptides requires proteasomes and the transporters associated with antigen processing, utilizing the classical endogenous antigen presentation pathway.
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