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  • Title: Ribosomes and secretory granules in human mast cells: close associations demonstrated by staining with a chelating agent.
    Author: Dvorak AM, Morgan ES.
    Journal: Immunol Rev; 2001 Feb; 179():94-101. PubMed ID: 11292032.
    Abstract:
    The distribution of ribosomes was investigated in mature human mast cells with a chelation-based staining protocol known to bleach DNA-rich structures, leaving RNA-rich structures unbleached. With this method, electron-dense ribosomes were adjacent to, attached to, and within secretory granules, which were also bleached with the chelation method that we used. The finding of these ribosome-secretory granule relationships suggests that secretory granules in mature human mast cells may participate in RNA metabolism.
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